Microarray Technology And Its Applications Pdf

microarray technology and its applications pdf

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The expectation that microarray technology will play a large role in shaping the future of pharmaceutical development and diagnostics has greatly increased due to new products and applications.

The DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes. Scientists know that a mutation - or alteration - in a particular gene's DNA may contribute to a certain disease. However, it can be very difficult to develop a test to detect these mutations, because most large genes have many regions where mutations can occur.

The Role of Microarray Technology in Pharmaceutical Development and Diagnostics

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Cancer is a highly variable disease with multiple heterogeneous genetic and epigenetic changes.

Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Probe-target hybridization is usually detected and quantified by detection of fluorophore -, silver-, or chemiluminescence -labeled targets to determine relative abundance of nucleic acid sequences in the target. Also for identification of structural variations and measurement of gene expression. The core principle behind microarrays is hybridization between two DNA strands, the property of complementary nucleic acid sequences to specifically pair with each other by forming hydrogen bonds between complementary nucleotide base pairs. A high number of complementary base pairs in a nucleotide sequence means tighter non-covalent bonding between the two strands. After washing off non-specific bonding sequences, only strongly paired strands will remain hybridized.

Importance of Microarray Technology and its Applications

Microarray is one of the most recent advances being used for cancer research; it provides assistance in pharmacological approach to treat various diseases including oral lesions. Microarray helps in analyzing large amount of samples which have either been recorded previously or new samples; it even helps to test the incidence of a particular marker in tumors. Till recently, microarray's usage in dentistry has been very limited, but in future, as the technology becomes affordable, there may be increase in its usage. Here, we discuss the various techniques and applications of microarray or DNA chip. Once the human genome sequence was completed in , it paved the way for many experiments and researches; one such area was identifying the regions of DNA which control normal and disease states.

Microarray Technology and Its Applications

David W. Galbraith galbraith arizona. Jeremy Edwards edwardsjd ufl. Recent advances in technology and in the ability to acquire, store, and analyze complex biological data sets have provided an unprecedented understanding of the mechanisms regulating living organisms' development and responses to the environment.

Metrics details. Microarrays are a powerful tool that have multiple applications both in clinical and cell biology arenas of common lung diseases. To exemplify how this tool can be useful, in this review, we will provide an overview of the application of microarray technology in research relevant to common lung diseases and present some of the future perspectives. Microarray technology is rapidly becoming a standard technology used in research laboratories all across the world.

It seems that you're in Germany. We have a dedicated site for Germany. The genomics revolution would not have been possible without the 'parallelisation' offered by microarray technology. This technological - and commercial - success has been since emulated by other applications areas, with a tremendous amplification of innovation. This book describes the fundamentals and latest developments in microarray technology, as well as its future directions.

DNA microarray

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DNA Microarray Technology Fact Sheet