Formulation And Evaluation Of Extended Release Tablets Pdf

formulation and evaluation of extended release tablets pdf

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Pharmacy College, Paloncha - , Telangana, India.

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The purpose of this research was to formulate and characterize solid dispersion SD of metformin hydrochloride using methocel KM as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy FTIR , ultraviolet, differential scanning calorimetry and X-ray powder diffractometry.

Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride

Rabeprazole, a member of substituted benzimidazoles, inhibits the final step in gastric acid secretions. This drug claims to cause fastest acid separation due to higher pKa , and more rapidly converts to the active species to aid gastric mucin synthesis. The most significant pharmacological action of Rabeprazole is dose dependent suppression of gastric acid secretion; without anticholinergic or H2-blocking action. It completely abolishes the hydrochloric acid secretion as it is powerful inhibitor of gastric acid. Rabeprazole is acid labile and hence commonly formulated as an enteric coated tablet. The absorption of rabeprazole occurs rapidly as soon as tablet leaves the stomach.

Formulation and Evaluation of Sustained Release Matrix Tablets of Nifedipine

Shailesh T. Prajapati, Amit N. Patel, Chhagan N. Tablets were prepared by melt granulation technique and evaluated for various evaluation parameters. Controlled-release CR formulations have been introduced into drug therapy with two main purposes: to reduce the number of single doses per day improving patient compliance of treatments and to decrease the fluctuations of plasma levels, in order to obtain better therapeutic efficacy and lower toxicity. There are many controlled-release pharmaceutical systems currently known, ranging from monolithic matrices, membrane reservoirs, erodible polymers, to the more technologically complex and sophisticated pH independent formulations, ion exchange resins, osmotically, and geometrically modified systems. Many of these systems are not produced in a form that is amenable to large-scale manufacturing processes and usually do not exhibit the desirable zero-order release kinetics.

Extended release matrix tablet of Metformin Hcl were formulated different combinations of polymers in Hydroxyl propyl methyl cellulose (HPMC K.


Conventional drug delivery system for treating the angina and hypertension are not much effective as the drug do not reach the site of action in appropriate amounts. Thus potent and guarded therapy of this angina and hypertension disorder using specific drug delivery system is a challenging task to the pharmaceutical professionals. Most oftenly used method of regulating the drug release is to include it in a matrix system because of their pliability, hydrophilic polymer matrices are widely used in oral controlled drug delivery to obtain a desirable drug release pattern, methodical, and broad regulatory compliance. Formulation of Nifedipine sustained release matrix tablet was prepared by the polymers blend with to get desirable drug release profile. Evaluation parameters of formulated tablets were hardness, friability, thickness, drug content uniformity weight variation, and the in vitro drug release rate pattern.

Methods: The tramadol matrix tablets were prepared by using different polymers like hydroxy propyl methyl cellulose HPMC K15M and KM , polyethylene oxide PEO as the nontoxic and easily available suitable matrix system. The extended release tablets of tramadol mg were prepared wet granulation technique. Different pre compression and post compression were performed. In vitro dissolution tests were performed and percentage drug release was calculated. Different release models like zero order, first order, higuchi and Korsemeyer-Peppas were applied to in vitro drug release data in order to evaluate the drug release mechanisms and kinetics.

Formulation and evaluation of extended release tablets of salbutamol sulphate

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