Inflammation Atherosclerosis And Coronary Artery Disease Pdf

inflammation atherosclerosis and coronary artery disease pdf

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Inflammation, Atherosclerosis and Coronary Artery Disease

Research into inflammation, atherosclerosis and coronary artery disease, including observational studies, clinical trials, epidemiology, and advances in applied translational research. The supplement is intended to include overviews of new concepts in pathophysiology, natural history, diagnostic strategies, and treatment approaches.

Article types include original clinical and basic research articles, case reports, commentaries, meeting reports, methodology, perspectives. Inflammation has been well recognized to play an important role in the development of atherosclerosis. However, these associations and precise mechanisms remain controversial. Several studies have suggested that more infectious pathogens, referred to as the infectious burden, rather than any single pathogen, may be involved in the development of atherosclerosis.

In , Ishizaka et al. Regarding the associations between inflammatory biomarkers and atherosclerotic diseases, many studies have demonstrated that elevated high sensitivity C-reactive protein hsCRP levels, which are one of the biomarkers of systemic inflammation, are a powerful predictor of future cardiovascular events, such as myocardial infarction MI and cardiac death.

They demonstrated that East Asians had low hsCRP levels and that, even in East Asians, elevated hsCRP levels were associated with an increased risk of stroke, especially ischemic stroke. Enomoto et al. In addition to hsCRP levels, some new inflammatory biomarkers related to both metabolic and atherosclerotic diseases have been reported. In this supplementary issue, Furuhashi et al. Elevated FABP4 levels were reported to be associated with obesity, diabetes mellitus and atherosclerotic diseases.

Notably, there is a male preponderance of death due to atherosclerotic diseases, especially CAD, at a younger age than women, thus suggesting that sex hormones may play a major role in the process of atherosclerotic diseases.

In this supplementary issue, Fairweather et al. Moreover, sex hormones are suggested to affect the process of myocardial inflammation and remodeling during myocarditis. Systemic inflammatory responses are considered to play a major role in the destabilization of atherosclerotic plaques.

The presence of inflammation in one artery is highly predictive of inflammation in other arteries. The glucose analogue 18 F-FDG is taken up by metabolically active cells, especially macrophages, thus allowing the detection of inflammatory activity. Using this 18 F-FDG tracer, positron emission tomography PET has become recognized as a reliable imaging technique for the detection of metabolic activity of atherosclerosis. In this supplementary issue, Alie et al. A modern lifestyle with high fat diet and lack of physical activity promotes atherosclerosis.

Obesity and high fat diet have been shown to be associated with chronic inflammation in human adipose tissues and arteries. The inverse associations between the consumption of vegetables, fruits and fish and atherosclerotic diseases have been reported in many epidemiological studies, showing a reduced risk of such diseases. However, there are still many unclear points regarding the contribution of these foods to the prevention of atherosclerosis.

In this supplementary issue, Saita et al. In addition to vegetables and fruits, antioxidant polyphenols are rich in beverages, such as wine and black and green tea. Recently, a meta-analysis showed green tea consumption to be associated with a reduced risk of CAD. In this supplementary issue, Ohmori et al. Moreover, they demonstrated the inhibitory effect of LDL oxidation and the anti-inflammatory effect of green tea in 22 healthy volunteers.

Inflammation is recognized to play an important role in both the initiation and progression of atherosclerotic diseases, such as CAD, however, the aim to prevent or treat atherosclerosis via modulating inflammation remains challenging. The articles in this supplementary issue of Clinical Medicine Insights: Cardiology encompass new research or timely reviews regarding inflammation, atherosclerosis and coronary artery disease.

He has previously worked at St. His research interests have focused on biomarkers, coronary artery disease, epidemiology, and MRI, especially plaque imaging. His research interests have focused on novel risk factors, coronary artery disease, and epidemiology, and he is also interested in trends in nutritional intake shown in the Tanushimaru Study, one of the original cohorts of the Seven Countries Study. His previous studies have been published in a variety of peer-reviewed journals including Hypertension, Journal of Hypertension, American Journal of Hypertension, Atherosclerosis and others.

Fairweather was responsible for papers on inflammation, atherosclerosis and coronary artery disease. Noel R. She now works primarily to understand how sex hormones and environmental co-exposures like infections and chemicals increase chronic inflammatory diseases like cardiovascular and autoimmune diseases. Fairweather has received funding from the national Institutes of Health, the American Heart Association, and industry. She has authored 70 manuscripts and book chapters and has given over 80 national and international presentations.

He received his MD from University Tokyo. She completed her PhD at Ochanomizu University. She now works primarily in developing understanding of inhibitory effects of nutritional factors on atherosclerosis. Other authors disclose no potential conflicts of interest. All authors have provided signed confirmation of their compliance with ethical and legal obligations including but not limited to use of any copyrighted material, compliance with ICMJE authorship and competing interests disclosure guidelines.

National Center for Biotechnology Information , U. Clin Med Insights Cardiol. Published online Aug Author information Copyright and License information Disclaimer. This article has been cited by other articles in PMC. Supplement Aims and Scope Research into inflammation, atherosclerosis and coronary artery disease, including observational studies, clinical trials, epidemiology, and advances in applied translational research.

Open in a separate window. Alexander RW. Inflammation and coronary heart disease. N Engl J Med. Ross R. Atherosclerosis: an inflammatory disease. Effects of total pathogen burden on coronary artery disease risk and C-reactive protein levels.

Am J Cardiol. Atherosclerosis as a possible extrahepatic manifestation of chronic hepatitis C virus infection. Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Eng J Med. C-reactive protein and cardiovascular disease in East Asians: a systematic review. Circulating inflammatory and hemostatic biomarkers are associated with all-cause death and cancer death in a population of community-dwelling Japanese: the Tanushimaru Study.

Fatty acid-binding protein 4 FABP4 : pathophysiological insights and potent clinical biomarker of metabolic and cardiovasular disease. Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study.

Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis. Arterioscler Thromb Vasc Biol.

Women and ischemic heart disease: evolving knowledge. J Am Coll Cardiol. Atherosclerosis and sex hormones: current concepts. Clin Sci. Fairweather D. Sex differences in inflammation during atherosclerosis. Circ Cardiovasc Imaging. Imaging atherosclerotic plaque inflammation with 18 F-fluorodeoxyglucose positron emission tomography. Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis.

Anti-inflammatory diet for atherosclerosis and coronary artery disease: antioxidant foods. Black and green tea consumption and the risk of coronary artery disease: a meta-analysis. Am J Clin Nutr. Antioxidant beverages: green tea intake and coronary artery disease. Articles from Clinical Medicine Insights.

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Inflammation, Atherosclerosis and Coronary Artery Disease

Atherosclerosis is a chronic inflammatory disease. Pathophysiological similarities between chronic infections and atherosclerosis triggered interest in a clinical association between these conditions. Various infectious microbes have been linked to atherosclerotic vascular disease in epidemiological studies. Identification of underlying pathophysiological mechanisms and experience with vaccination against various infectious agents has ushered a new avenue of efforts in the development of an anti-atherosclerotic vaccine. Studies in animal models have identified various innate and adaptive immune pathways in atherosclerosis. In this review, we discuss the patho-biological link between chronic infections and atherosclerosis, evaluate existing evidence of animal and human trials on the association between infections and cardiovascular disease and introduce the concept of an anti-atherosclerotic vaccine.

Inflammation, atherosclerosis, and coronary artery disease.

Research into inflammation, atherosclerosis and coronary artery disease, including observational studies, clinical trials, epidemiology, and advances in applied translational research. The supplement is intended to include overviews of new concepts in pathophysiology, natural history, diagnostic strategies, and treatment approaches. Article types include original clinical and basic research articles, case reports, commentaries, meeting reports, methodology, perspectives.

Cardiovascular disease CVD remains the leading cause of mortality and morbidity worldwide. Atherosclerosis is responsible for the majority of cardiovascular disorders with inflammation as one of its driving processes. Cardiovascular disease CVD remains the leading cause of mortality and morbidity worldwide, despite major improvements in treatment and outcomes. CVD is a group of diseases that effects the heart and blood vessels including coronary artery disease CAD , cerebrovascular disease, and peripheral artery disease [ 1 , 2 ].

Key words:. Global, regional, and national age-sex specific all-cause and cause-specific mortality for cau of death, a systematic analysis for the Global Burden of Disease Study Lancet London, England [Internet] ;

Inflammation, atherosclerosis, and coronary artery disease

Atherosclerosis is a multifactorial disease triggered and sustained by different risk factors such as dyslipidemia, arterial hypertension, diabetes mellitus, smoke, etc.

What causes coronary artery disease?

Вы не шутите. - Если бы я шутил… Я поставил его вчера в одиннадцать тридцать вечера. Шифр до сих пор не взломан. Сьюзан от изумления застыла с открытым ртом. Она посмотрела на часы, потом на Стратмора.

Мидж и раньше были свойственны фантазии, но ведь не. Он попробовал ее успокоить: - Джабба, похоже, совсем не волнуется. - Джабба - дурак! - прошипела. Эти слова его удивили. Никто никогда не называл Джаббу дураком, свиньей - быть может, но дураком -. - Свою женскую интуицию ты ставишь выше ученых степеней и опыта Джаббы в области антивирусного программирования.

Неужели АНБ прослушивает мои телефонные разговоры. Стратмор виновато улыбнулся. - Сегодня утром Дэвид рассказал мне о ваших планах. Он сказал, что ты будешь очень расстроена, если поездку придется отложить. Сьюзан растерялась. - Вы говорили с Дэвидом сегодня утром.

5 COMMENTS

Ocdimwavi

REPLY

Our knowledge of the pathophysiology of atherosclerosis and the development of acute coronary syndrome ACS has progressed over the last few decades thanks to the large number of studies on the proliferation of smooth muscle cells, growth factors, and the biology of the vascular bed.

Lebikinmu

REPLY

Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart called coronary arteries.

Alidia O.

REPLY

PDF | ecent research has shown that inflammation plays a key role in coronary artery disease (CAD) and other manifestations of.

Karlotta C.

REPLY

Request PDF | On Jan 1, , G.K. Hansson published Inflammation, atherosclerosis, and coronary artery disease | Find, read and cite all the research you.

Ovidio M.

REPLY

It will recount the evidence that atherosclerosis, the main cause of CAD, is an inflammatory disease in which immune mechanisms interact with.

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