Crystal Growth Of Cholesterol In Hydrogels And Its Characterization Pdf

crystal growth of cholesterol in hydrogels and its characterization pdf

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Colorimetric detection of ultratrace cholesterol by free standing inverse opal hydrogel films

Currently, there are many hydrogels used in many important biomedical fields such as therapeutic delivery, contact lenses, corneal prosthesis, bone cements, wound dressing, 3D tissue scaffolds for tissue engineering, etc. Thus, new advanced hydrogels have been developed as multicomponent systems in the form of composite or nanocomposite materials, which are expected to exhibit superior properties to increase the potential uses of these materials in the biomedical industry. Even though the great advances achieved so far, much research has to be conducted still in order to find new strategies to fabricate novel hydrogels able to overcome many of these problems. Hydrogels are used in many fields of the biomedical industry such as therapeutic delivery [ 1 ], intraocular lenses, contact lenses and corneal prosthesis in ophthalmology [ 2 ], bone cements for orthopedics [ 3 ], wound dressing [ 4 ], 3D tissue scaffolds in regenerative medicine [ 5 ], etc. The enhancement of mechanical properties is one of the most desirable achievements in the field of hydrogel engineering and many researchers are currently working in this complex scientific area. Most hydrogels possesses very low mechanical properties, especially in the swollen state. Thus, hydrogels can be reinforced through many established kinds of methods and techniques: block copolymers, in which hydrophobic and hydrophilic domains alternate [ 7 ], increasing crosslinking density [ 8 ], by means of binary systems composed of two or more mixed polymers as interpenetrating polymer networks [ 9 ], by plasma grafting of a hydrogel onto a hydrophobic substrate [ 10 , 11 , 12 ], self-reinforced composite materials composed of fibers embedded in a matrix of the same polymer [ 13 ] and with the sol—gel reaction to produce nanosilica reinforcement [ 14 ].

Morphological Characterization of Hydrogels

Domenico Lombardo, Mikhail A. The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This article highlights recent advances of smart nanocarriers composed of organic including polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels and inorganic including quantum dots, gold and mesoporous silica nanoparticles materials. This highlights some critical issues in the design and engineering of nanocarrier systems for biotechnology applications, arising from the complex environment and multiform interactions established within the specific biological media. In the last decades, the development of novel approaches for the construction of nanoformulations nanocarriers for the efficient transport of drug molecules offers a wide range of biotechnology applications [ 1 , 2 ]. In particular, they allow resolving the main critical issues encountered with conventional pharmaceutical treatments such as the nonspecific distribution, rapid clearance, uncontrollable release of drugs, and low bioavailability [ 3 — 5 ]. This highlights some critical issues in the design and engineering of nanocarrier systems for biotechnology applications, arising from the complex environment and multiform interactions established within the specific biological media [ 6 — 8 ].

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In vitro cell compatibility study suggested that 3T3 is fibroblasts exhibited better initial cell adhesions and higher proliferation rates on the composite hydrogel than on the polystyrene control plate and the pure LC membrane. The interest in hydrogels for tissue engineering applications has increased owing to their capacity of designable mechanical properties and water content. Hydrogels are water-swollen, crosslinked polymer networks with mechanical behaviours similar to rubber-like materials [ 1—3 ], such as tissue-like elasticity and time-dependent viscoelastic behaviours.

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