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- Development of soft sensors for monitoring and control of bioprocesses
- Improvement of bioprocess monitoring: development of novel concepts
- Top PDF Near infrared spectroscopy technique for bioprocess monitoring and control
The production of fuels and chemicals from lignocellulosic biomass demands efficient processes to compete with fossil fuel-derived products. Key biorefinery processes, such as enzymatic hydrolysis of cellulose and microbial fermentation, can be monitored by advanced sensors in real time, providing information about reactant and product concentration, contamination, and reaction progress. Spectroscopic techniques such as Raman spectroscopy provide a means of quickly and accurately assessing many types of reaction mixtures non-destructively, in real time, and with no costly sample preparation and analysis time. Raman spectroscopy techniques have been developed to accurately quantify a number of compounds present in lignocellulosic processes, and methods have been developed to overcome the presence of fluorescent compounds that can increase the spectral background.
Development of soft sensors for monitoring and control of bioprocesses
The advancement of bioprocess monitoring will play a crucial role to meet the future requirements of bioprocess technology. Major issues are the acceleration of process development to reduce the time to the market and to ensure optimal exploitation of the cell factory and further to cope with the requirements of the Process Analytical Technology initiative. Due to the enormous complexity of cellular systems and lack of appropriate sensor systems microbial production processes are still poorly understood. This holds generally true for the most microbial production processes, in particular for the recombinant protein production due to strong interaction between recombinant gene expression and host cell metabolism. Therefore, it is necessary to scrutinise the role of the different cellular compartments in the biosynthesis process in order to develop comprehensive process monitoring concepts by involving the most significant process variables and their interconnections. Although research for the development of novel sensor systems is progressing their applicability in bioprocessing is very limited with respect to on-line and in-situ measurement due to specific requirements of aseptic conditions, high number of analytes, drift, and often rather low physiological relevance.
With this license, the DASware control software installed on site is accessible by one or more remote clients simultaneously. Users can enable either remote monitoring and control or just remote monitoring of their bioprocesses, depending on the user-defined configuration and associated authentication. Broad functionality Remotely observe and control running Ordering information Description Order no. Remote Control 4 Pages Add to favorites. Catalog excerpts. Open the catalog to page 2.
Improvement of bioprocess monitoring: development of novel concepts
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Gustavsson Published Computer Science. In the manufacture of bio-therapeutics the importance of a well-known process is key for a high product titer and low batch to batch variations. Soft sensors are based on the concept that online se
These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Recent advances in analytical instrumentation, biosensors and computer technology have lead to the development of new approaches and techniques to control and optimize bioprocesses. Use of on-line measurements to monitor bioprocesses for identifying physiological state of cells and controlling environmental conditions to maintain the cells in the optimal physiological state has become more prevalent.
Figure 1. General presentation of the computerized bioprocess control . 2. Instruments and techniques for bioprocess variables determination and monitoring.
Top PDF Near infrared spectroscopy technique for bioprocess monitoring and control
Over the past decade, the application of chemical optical sensors for bioprocess monitoring has gradually taken roots. Constant further development of this measurement technology and the possibility to manufacture such sensors in various designs even for single-use applications have led to new state-of-the-art devices for the biotechnology sector. Chemical optical sensors enable in situ, real-time monitoring of important culture parameters without sampling and therefore without disturbing a culture. Implementing this technology can decrease workloads and deepen knowledge about bioprocesses.
Head of Upstream Process Development, Nasdaq-listed biopharmaceuticals company. It enables us to monitor and control our novel processes for vitamin production". Ben Caddell, Fermentation Scientist, Biosyntia. The integration is made easy by integrated workflows and a high degree of automation.
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